UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                           __________________________


                                    FORM 8-K

                                 CURRENT REPORT
                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934


       Date of report (Date of earliest event reported): October 25, 2004

                                   __________


                             SIGA Technologies, Inc.
               (Exact Name of Registrant as Specified in Charter)

            Delaware                   0-23047                 13-3864870
            --------                   -------                 ----------

 (State or other Jurisdiction of   (Commission File          (I.R.S. Employer
  Incorporation or Organization)        Number)           Identification Number)


   420 Lexington Avenue, Suite 601, New York, New York                 10170
   ---------------------------------------------------                 -----

        (Address of Principal Executive Offices)                     (Zip Code)


                                 (212) 672-9100
              (Registrant's telephone number, including area code)

ITEM 7.01. Regulation FD Disclosure. On October 25, 2004, SIGA Technologies, Inc., a Delaware corporation, issued a press release pursuant to which it announced that Dr. Dennis Hruby, SIGA's Chief Scientific Officer, will present at the Rodman & Renshaw Techvest 6th Annual Healthcare Conference on Wednesday, October 27th at 10:50am EST. A live webcast of this presentation will be available at: http://www.wallstreetwebcasting.com/webcast/rrshq4/siga/ or via the Company's website at www.siga.com. An archived presentation will be available for 90 days. A copy of the press release is attached hereto as Exhibit 99.1, which is incorporated in this Item 7.01 by reference. ITEM 9.01 Financial Statements and Exhibits (c) Exhibits Exhibit No. Description ----------- ----------- 99.1 Press Release dated October 25, 2004. 2

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. SIGA TECHNOLOGIES, INC. By: /s/ Thomas N. Konatich ----------------------------- Thomas N. Konatich Chief Financial Officer Date: October 25, 2004 3

EXHIBIT INDEX Exhibit Number Description - -------------- ----------- 99.1 Press Release dated October 25, 2004 4

                                                                    Exhibit 99.1


SIGA

Contact:                                              Investor Contact:
Dr. Bernard Kasten                                    Dianne Will
SIGA Technologies, Inc.                               Willstar Consultants, Inc.
Chief Executive Officer                               (518) 398-6222
(212) 672-9100                                        dwill@willstar.net
                                                      ------------------




    SIGA TECHNOLOGIES TO PRESENT AT THE RODMAN & RENSHAW TECHVEST 6TH ANNUAL
                      HEALTHCARE CONFERENCE ON OCOTBER 27th

New York, NY - October 25, 2004 - SIGA Technologies, Inc. (NASDAQ: SIGA)
announced today that Dr. Dennis Hruby, SIGA's Chief Scientific Officer, will
present at the Rodman & Renshaw Techvest 6th Annual Healthcare Conference on
Wednesday, October 27th at 10:50am EST. A live webcast of this presentation will
be available at: http://www.wallstreetwebcasting.com/webcast/rrshq4/siga/ or via
the Company's website at www.siga.com. An archived presentation will be
available for 90 days.

"We look forward to increasing the awareness about our development programs in
the areas of vaccines and anti-infectives to prevent or treat diseases caused by
Category A Pathogens as defined by the Centers for Disease Control and
Prevention (CDC), said Dr. Hruby. "During the presentation we will give an
update on our pre-clinical research in smallpox and viral hemorrhagic fevers."

SIGA recently announced that the company's lead smallpox  compound,  SIGA-246,
has demonstrated  significant  antiviral activity against several mouse models
of  poxvirus  disease.  In  one  of  these  studies,  oral  administration  of
SIGA-246  protected  mice from lethal doses of  ectromelia  virus.  Ectromelia
virus is closely  related to human smallpox virus and causes a similar type of
disease in mice (i.e.  mousepox).  SIGA-246  also was found to reduce  disease
spread and lesion formation in treated mice with no obvious toxicity.

The Rodman & Renshaw Techvest 6th Annual Healthcare Conference will be held at
The Waldorf Astoria Hotel in New York City. Analysts and portfolio managers are
invited to attend this presentation by contacting Rodman & Renshaw Conference
Information at (212) 356-0529 to register or register on-line at
http://www.rodmanandrenshaw.com/rodman.asp?link=Conferences3/
ConferenceMain&bgcolor=wht.

About SIGA Technologies, Inc.

SIGA Technologies is applying bacterial genomics in the design and development
of novel products for the prevention and treatment of serious infectious
diseases, with an emphasis on products for biological warfare defense. SIGA has
the potential of becoming a significant force in the discovery of vaccine and
pharmaceutical agents to fight emerging pathogens. SIGA's product development
programs emphasize the increasingly serious problem of drug resistant bacteria
and emerging pathogens. SIGA's vaccine and drug platforms are based on its
pioneering research into the structure, function and processing of bacterial
surface proteins. SIGA is leveraging these platforms through multiple strategic
partners, including the National Institutes of Health and TransTech Pharma, Inc.
For more information about SIGA, please visit SIGA's Web site at www.siga.com.

This news release contains certain "forward-looking statements" within the
meaning of the Private Securities Litigation Reform Act of 1995. Such
statements, including statements regarding the efficacy and intended utilization
of SIGA's technologies under development, are not guarantees of future
performance. Actual results may differ materially from the expectations
contained in the forward-looking statements. Factors that may cause such
differences include the risk that potential products that appeared promising in
early research or clinical trials to SIGA or its collaborators do not
demonstrate efficacy or safety in subsequent pre-clinical or clinical trials,
and the risk that SIGA or its collaborators will not obtain appropriate or
necessary governmental approvals to market products tested in such trials. More
detailed information about SIGA and the factors discussed above is set forth in
SIGA's filings with the Securities and Exchange Commission, including SIGA's
Annual Report on Form 10-K for the fiscal year ended December 31, 2003, and in
other documents that SIGA has filed with the U.S. Securities and Exchange
Commission. Investors and security holders are urged to read those documents
free of charge at the Commission's web site at www.sec.com. Those documents may
also be obtained free of charge from SIGA. SIGA does not undertake to publicly
update or revise its forward-looking statements as a result of new information,
future events or otherwise.